Global microarray analysis of ONECUT2 transcription factor overexpression in human prostate cancer cells
Treatment of prostate cancer by hormone suppression leads to the appearance of aggressive variants with variable or no dependence on the androgen receptor. Here we show that the developmental transcription factor, ONECUT2, is a master regulator of the AR network that is highly active in castration-resistant prostate cancer (CRPC).
Cancer Type: Prostate Cancer
GPL: 570
Number of Genes with Data: 978
Number Observations: 18
Number Outputs: 2
Imbalanced Ratio: 0.5
Default Task: Classification