Gene Signature for Aggression of Melanoma Metastases - Melanoma Metastasis
Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. Keywords: disease state
Cancer Type: Melanoma
GPL: 96
Number of Genes with Data: 978
Number Observations: 83
Number Outputs: 1
Imbalanced Ratio: 0.596153846
Default Task: Classification