TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [adenomas]
Colorectal cancer can be divided into four consensus molecular subtypes, which might associate with distinct precursor lesions. The aim of this study was to determine the subtype affiliation of two types of colorectal adenomas: tubular adenomas (TAs) and sessile serrated adenomas (SSAs) and to determine the activity of TGFβ signaling and the role of this cytokine in subtype affiliation. Adenoma samples were collected in the Academic Medical Center (AMC), Amsterdam, The Netherlands. Tubular adenomas (TAs) were obtained from familial adenomatous polyposis (FAP) patients and sessile serrated adenomas (SSAs) were collected from serrated polyposis syndrome (SPS) patients.
Cancer Type: Colorectal Cancer
GPL: 13158
Number of Genes with Data: 978
Number Observations: 16
Number Outputs: 2
Imbalanced Ratio: 0.777777778
Default Task: Classification