A Molecular Profile of Colorectal Cancer to Guide Therapy [HMEC]

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Here we describe the generation and application of a gene expression signature for the Rheb pathway. Affymetrix array data obtained from human mammary epithelial cells over expressing Rheb or GFP were used to generate a Rheb/mTOR activation signature. To test the capacity of the signature to predict patient response to everolimus we treated patient-derived colorectal cancer explants (PDCCEs) predicted to have high and low Rheb pathway activity withthe mTOR inhibitor everolimus.

Cancer Type: Colorectal Cancer

GPL: 571

Number of Genes with Data: 978

Number Observations: 20

Number Outputs: 1

Imbalanced Ratio: 1

Default Task: Classification