Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database

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Anticancer drug clustering in lung cancer based on gene expression profiles. We performed gene expression analysis in lung cancer cell lines. (used: Affymetrix GeneChip Human Genome U133 Array Set HG-U133A). We also examines the sensitivity of these cell lines to commonly used anti-cancer agents (docetaxel, paclitaxel, gemcitabine, vinorelbine, 5-FU, SN38, cisplatin, and carboplatin) via MTT assay. We related the cytoxic activity of each of these agents to corresponding expression pattern in each of the cell lines using modified NCI program. Keywords: cytotoxicity, lung cancer, anticancer drugs

Cancer Type: Lung Cancer

GPL: 96

Number of Genes with Data: 978

Number Observations: 29

Number Outputs: 1

Imbalanced Ratio: 0.9

Default Task: Classification