The effect of ACSL4 expression on overall gene expression in breast cancer cell lines
ACSL4 expression appears to be inversely associated with steroid hormone and growth factor receptor expression in breast cancer and positively correlated with an aggressive breast cancer phenotype. Neither MCF-7 nor SKBr3 cells normally express ACSL4, and when manipulated to do so, develop basal-like characteristics, including increased proliferation, migration and anchorage independent growth. We used an Affymetrix array platform to assess changes in individual gene expression as a function of conditional and stable expression of ACSL4 in MCF-7 and SKBr3 cells.
Cancer Type: Breast Cancer
GPL: 570
Number of Genes with Data: 978
Number Observations: 18
Number Outputs: 3
Imbalanced Ratio: 0.5
Default Task: Classification