Expression data of EZH2-dependent genes in prostate cancer cell lines
EZH2 is frequently over-expressed in aggressive and metastatic solid tumors, including castration resistant prostate cancer (CRPC). We sought to determine EZH2-dependent gene expression programmes in prostate cancer progression, and found an intriguing functional switch of EZH2 from a repressor to an activator during CRPC development. We used microarrays to detail the global profiling of gene expression that are differentially regulated upon EZH2 depletion in two different prostate cancer cell lines.
Cancer Type: Prostate Cancer
GPL: 570
Number of Genes with Data: 978
Number Observations: 12
Number Outputs: 2
Imbalanced Ratio: 1
Default Task: Classification