Breast cancer and liver tissue biopsies used to develop and validate an index for liver contamination in metastatic breast cancer
PURPOSE: To develop an index capable of detecting and quantifying the extent of liver RNA contamination in liver biopsies of metastatic breast cancer METHODS: We developed a microarray-based gene expression liver index by comparing the expression levels of genes in liver tissue biopsies and in primary breast cancer biopsies. The predictive performance of the index was then evaluated in defined mixtures of liver and breast cancer RNA. A calibration curve was established to allow estimation of the liver RNA content in unknown metastatic breast cancer samples.
Cancer Type: Breast Cancer
GPL: 96
Number of Genes with Data: 978
Number Observations: 203
Number Outputs: 1
Imbalanced Ratio: 0.118181818
Default Task: Classification