Hyperactivation of PI3K promotes escape from hormone dependence in estrogen receptor-positive breast cancer

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Hyperactivation of phosphatidylinositol-3 kinase (PI3K) promotes escape from hormone dependence in estrogen receptor-positive breast cancer. A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. We used gene expression microarrays to identify genes and pathways that are commonly dysregulated in ER+ cell lines with acquired hormone-independent growth. MCF-7, ZR75-1, MDA-361, and HCC-1428 ER+, estrogen-responsive breast cancer cells were cultured under hormone-depleted conditions (10% DCC-FBS) for several months until sustainable hormone-independent cell populations emerged.

Cancer Type: Breast Cancer

GPL: 570

Number of Genes with Data: 978

Number Observations: 24

Number Outputs: 2

Imbalanced Ratio: 1

Default Task: Classification